Effects of ischemic preconditioning at different occlusion pressures on physical, clinical, and perceptual outcomes: a randomized placebo-controlled clinical trial

• Grant number: 22/14414-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2023
• End date: December 31, 2023
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Franciele Marques Vanderlei
• Grantee: Guilherme Henrique da Silva Brandão
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Introduction: in recent years, an interest in ischemic preconditioning (IPC) has grown considerably, characterized as a procedure prescribed by intermittent applications of vascular occlusion cycles. Due to its easy access and low cost, it represents an attractive ergogenic resource to increase the performance of athletes, however, the best dose-response regarding the different occlusion pressures is still unclear. Objectives: to analyze and compare the effect of different IPC occlusion pressures on physical (maximal isometric intentional contraction [MIVC]), clinical (pressure pain threshold, bioelectrical impedance [BIA] and myotonometry) and perceptive (pain perception and recovery). Methods: A randomized placebo-controlled clinical trial will be carried out with 80 healthy men aged between 18 and 35 years who will be randomly divided into four groups: PCI using total occlusion pressure (POT); PCI with 40% more than the POT; placebo (10 mmHg) and control. The PCI protocol will consist of four cycles of ischemia and reperfusion of five minutes each, totalling 40 minutes, while the placebo protocol will perform an intervention similar to the PCI protocol, but with four cycles of five minutes of alternating placebo occlusion (10mmHg) with four cycles of five minutes of reperfusion (0 mmHg). The control group will remain at rest for 40 minutes. Initially, the participants will rest for 10 minutes and then the total occlusion pressure (POT) will be evaluated. Subsequently, baseline estimates of the outcomes will be performed, sequentially being a pain by the visual analogue scale (VAS), perception of recovery by the Likert scale and effort by the Borg scale (CR-10), pain threshold by the pressure algometer, tonus, muscle resistance and elasticity by myotonometry, cell integrity vectors by BIA and CVIM by isokinetic dynamometry. Afterwards, the participants will perform the previously randomized intervention protocol and immediately after the intervention protocols, all outcomes will be selected again. The descriptive statistical method and analysis of variance will be used for the repeated measures model in the two-factor scheme with a significance level of p<0.05.