Scholarship 22/00427-3 - Citogenética, Evolução molecular - BV FAPESP
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Origin and differentiation of the multiple X1X2Y sex chromosome system: Satellitome analysis in fish, reptile, and mammal species.

Grant number: 22/00427-3
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Start date until: April 01, 2023
End date until: March 31, 2028
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Principal Investigator:Marcelo de Bello Cioffi
Grantee:Gustavo Akira Toma
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):24/16036-9 - Cytogenomics analysis in the multiple X1X2Y sex chromosomes of the Burton legless lizard Lialis burtonis (Pygopodidae; Squamata): A Comprehensive Approach Using Multi-Genetic Tools., BE.EP.DD

Abstract

The present project aims to integrate cytogenetic and genomic analyzes to investigate the origin and differentiation of the multiple @X1X1X2X2/BX1X2Y sex chromosome system. The isolation and characterization of the satellite DNA library (satellitome) from different vertebrate groups (fish, reptiles and mammals) will be carried out. To this end, fish (the trahira Hoplias malabaricus and the jeju Erythrinus erythrinus), reptile (the legless lizard, Lialis burtonis) and mammal (the night monkey, Aotus infulatus) species were selected as models. Subsequently, comparative analyzes of the chromosomal distribution pattern of these satellites, not only between males and females, but also in congeneric species carrying the @XX/BXY system, will provide conditions to investigate the processes of chromosomal differentiation that occurred after the initial rearrangements that triggered the multiple systems, thus making it possible to advance in the knowledge of their origin and differentiation. The selection of different vertebrate models that have different genomic characteristics regarding the amount of repetitive sequences present in their genomes can clarify distinct evolutionary scenarios regarding the accumulation/loss of repetitive DNAs in the specific sex chromosome (neo-Y). At the same time, the project will foster the integration of a network of national and international researchers, equally interested in the subject to be investigated, enabling its execution and obtaining promising results for cytogenetics and evolutionary genetics. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, GUILHERME MOTA; KRETSCHMER, RAFAEL; TOMA, GUSTAVO AKIRA; DE OLIVEIRA, ALAN MOURA; DEON, GEIZE APARECIDA; SETTI, PRINCIA GREJO; DOS SANTOS, RODRIGO ZENI; GOES, CAIO AUGUSTO GOMES; GARNERO, ANALIA DEL VALLE; GUNSKI, RICARDO JOSE; et al. Satellitome analysis on the pale-breasted thrush Turdus leucomelas (Passeriformes; Turdidae) uncovers the putative co-evolution of sex chromosomes and satellite DNAs. SCIENTIFIC REPORTS, v. 14, n. 1, p. 14-pg., . (23/00955-2, 22/14584-3, 22/00427-3)
DE OLIVEIRA, ALAN MOURA; SOUZA, GUILHERME MOTA; TOMA, GUSTAVO AKIRA; DOS SANTOS, NATALIA; SANTOS, RODRIGO ZENI DOS; GOES, CAIO AUGUSTO GOMES; DEON, GEIZE APARECIDA; SETTI, PRINCIA GREJO; PORTO-FORESTI, FABIO; UTSUNOMIA, RICARDO; et al. Satellite DNAs, heterochromatin, and sex chromosomes of the wattled jacana (Charadriiformes; Jacanidae): a species with highly rearranged karyotype. GENOME, v. 67, n. 4, p. 10-pg., . (22/14585-0, 22/00427-3)
TOMA, GUSTAVO AKIRA; SEMBER, ALEXANDR; GOES, CAIO AUGUSTO GOMES; KRETSCHMER, RAFAEL; PORTO-FORESTI, FABIO; BERTOLLO, LUIZ ANTONIO CARLOS; LIEHR, THOMAS; UTSUNOMIA, RICARDO; DE BELLO CIOFFI, MARCELO. Satellite DNAs and the evolution of the multiple X1X2Y sex chromosomes in the wolf fish Hoplias malabaricus (Teleostei; Characiformes). SCIENTIFIC REPORTS, v. 14, n. 1, p. 13-pg., . (23/00955-2, 22/00427-3)

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