EFFECTS OF PHOTOBIOMODULATION ON BLOOD PRESSURE IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS

• Grant number: 23/10073-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2024
• End date: December 31, 2024
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Cleber Ferraresi
• Grantee: Giovana Pereira dos Santos
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Introduction: Type 2 diabetes mellitus (DM2) is a chronic and multifactorial condition that may cause cardiovascular complications and double the chances of elevated blood pressure (BP). In this context, photobiomodulation (FBM) has been investigated as a non-invasive and non-pharmacological therapy for the treatment of DM2 and, more recently, blood pressure control, an area that has several studies in animal models, but clinical trials are still scarce. Objective: To analyze the effects of photobiomodulation on BP in DM2 individuals through ambulatory blood pressure monitoring (ABPM) before and after whole-body irradiation using a panel of LEDs (light-emitting diodes) with a wavelength of 850 nm. Systolic and diastolic BP will be analyzed, as well as the variation in BP over 24 hours after whole-body irradiation. Methodology: 36 volunteers, aged 50 to 70 years old, diagnosed with DM2, hypertensive and/or normotensive, will participate in the study and will be randomly allocated into two equal groups: sham and panel. Volunteers will undergo 6 photobiomodulation sessions over 2 weeks, with 3 sessions per week, on non-consecutive days. BP measurement will be taken before and after the photobiomodulation intervention. During the intervention period, BP will be monitored using the MAPA device on three days (first, eighth and last). The data will be analyzed for normality of distribution and a significance level of 5% will be adopted for intra and intergroups comparisons.