Genomic investigation of probiotics/bacteriocins for the treatment of antimicrobial-resistant pathogens

• Grant number: 23/16216-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: February 01, 2024
• End date: May 31, 2025
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Sergio Schenkman
• Grantee: João Pedro Rueda Furlan
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 21/10599-3 - The Antimicrobial Resistance Institute of São Paulo (The Aries Project), AP.CEPID

Abstract

Genomic analysis for identification of probiotics/bacteriocins. Analysis of resistomes, virulomes, and phylogenomics of critical-priority antimicrobial-resistant pathogens circulating in the food chain (livestock, dairy cattle, meat), in Brazil. Conceptualization, methodology, investigation and strategies for project development. Obtaining big data and incorporation/update of genomic and microbiological data into the OneBR platform (http://www.onehealthbr.com/). Application of probiotic/bacteriocin research for decolonization of host colonized by virulent and/or antimicrobial-resistant pathogens. In vivo models for testing probiotics/bacteriocins. DNA extractions, sequencing and library preparations. Analysis of data. Writing, review and editing of manuscripts, reports and patents.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, MEIRE MARIA; SELLERA, FABIO PARRA; FURLANE, JOAO PEDRO RUEDA; ARAVENA-RAMIREZ, VALENTINA; FUENTES-CASTILLO, DANNY; FUGA, BRUNA; FROESI, ALEXANDRE JOSE DOS SANTOS; DE SOUSAI, ALANA LISLEA; GARINO JUNIOR, FELICIO; LINCOPAN, NILTON. Gut colonization of semi-aquatic turtles inhabiting the Brazilian Amazon by international clones of CTX-M-8-producing Escherichia coli. Veterinary Microbiology, v. 301, p. 8-pg., 2024-12-23. (20/08224-9, 23/16216-4)

LI, XINYANG; ZHUANG, YILU; YU, YAWEN; JIA, HUIQIONG; KONG, YINGYING; ZHANG, JUN; XIE, XINYOU; STEHLING, ELIANA GUEDES; FURLAN, JOAO PEDRO RUEDA; ZHOU, ZHEMIN; et al. Interplay of multiple carbapenemases and tigecycline resistance in Acinetobacter species: a serious combined threat. Clinical Microbiology and Infection, v. 31, n. 1, p. 6-pg., 2024-12-16. (23/16216-4)

JIA, HUIQIONG; TONG, QINGCHAO; WANG, LE; WU, YUYE; LI, XINYANG; LI, SHUANGSHUANG; KONG, YINGYING; ZHANG, YINGYING; FURLAN, PEDRO RUEDA; KHINE, NWAI OO; et al. Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain. DRUG RESISTANCE UPDATES, v. 79, p. 4-pg., 2024-12-27. (23/16216-4)

ZHUANG, YILU; LI, SHUANGSHUANG; BAO, DANNI; FURLAN, JOAO PEDRO RUEDA; RUAN, ZHI. Genomic integrity in Bordetella pertussis: avoiding contaminant-derived misinterpretations of acquired antimicrobial resistance. Journal of Infection, v. 89, n. 6, p. 2-pg., 2024-12-01. (23/16216-4)

FURLAN, JOAO PEDRO RUEDA; SELLERA, FABIO PARRA; LINCOPAN, NILTON; DEBONE, DANIELA; MIRAGLIA, SIMONE GEORGES EL KHOURI; TAVELLA, RONAN ADLER. Catastrophic floods and antimicrobial resistance: Interconnected threats with wide-ranging impacts. ONE HEALTH, v. 19, p. 3-pg., 2024-12-01. (23/16216-4, 24/02579-0, 23/04466-6, 24/02476-7)

FURLAN, JOAO PEDRO RUEDA; ZARRILLI, RAFFAELE; DAOUD, ZIAD; HE, FANG; RUAN, ZHI. Editorial: Global dissemination and evolution of epidemic multidrug-resistant Gram-negative bacterial pathogens: surveillance, diagnosis and treatment, volume III. FRONTIERS IN MICROBIOLOGY, v. 16, p. 4-pg., 2025-03-12. (23/16216-4)

SELLERA, FABIO PARRA; ZHUANG, YILU; LINCOPAN, NILTON; STEHLING, ELIANA GUEDES; SCHENKMAN, SERGIO; RUAN, ZHI; FURLAN, JOAO PEDRO RUEDA. Genomic tracking the coexistence of mcr and carbapenemase genes in Gramnegative bacteria: a global perspective. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 64, n. 5, p. 3-pg., 2024-10-16. (23/16216-4)