Genetic variants associated with the response to treatment of bipolar affective disorder: a systematic review.

• Grant number: 24/02603-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2024
• End date: May 31, 2025
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Marcela Forgerini
• Grantee: Ana Luiza da Silva Selani
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Introduction: Bipolar affective disorder (BPAD) is a prevalent mood disorder that is associated with serious outcomes when there is no response to pharmacotherapy, such as a high risk of suicide, illicit substance abuse, and a tendency to violence. The treatment for BPAD consists of the use of mood stabilizers and antipsychotics, and there are reports in the literature that the presence of genetic variants can have an impact on the response to pharmacotherapy. Objective: It is intended to identify the genetic variants that influence the response to pharmacotherapy for BPAD. Methods: A systematic review will be carried out in the PubMed, Scopus, PsycINFO, and Lilacs databases based on the guiding question "What are the genetic variants that influence the response to pharmacotherapy for BPAD?". Clinical trials, casecontrol studies, cohorts, cross-sectional studies and case reports and series will be included. Systematic reviews, abstracts presented at scientific events, theses, dissertations, studies conducted in vivo and in vitro will be excluded. The stages of screening, eligibility, and analysis of the methodological quality of the studies will be carried out in duplicate. Expected results: To identify genetic variants that impact on the response to drug treatment for BPAD to promote the effectiveness and safety of pharmacotherapy, in addition to contribute genetic data to support health professionals in the decision-making process. It is also expected to write an article with the data obtained, an abstract for presentation at a scientific event and preparing educational material for scientific literacy.Keywords: Bipolar disorder; Drug therapy; Mood disorders; Pharmacogenetics; Pharmacogenomic Variants; Polymorphism, Genetic.