Histological and protein effects of the absence of adiponectin and relationship with IGF-1 in obesity, and resistance training.

• Grant number: 23/18257-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2024
• End date: December 31, 2025
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Cintia Yuri Matsumura
• Grantee: Ana Beatriz Garcia
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Obesity, a global public health issue, is characterized by an excess of body fat caused by nutritional imbalance where food intake exceeds energy expenditure. Excessive adipose tissue secretes pro-inflammatory cytokines, resulting in an inflammatory condition associated with comorbidities. The provision of a high-fat diet serves as a preclinical model for studying obesity, increasing adipose tissue and inducing inflammation similar to humans. While the overall body's energy metabolism is affected in individuals with overweight and obesity, studies have focused on the detrimental effects that obesity has on the metabolic function of skeletal muscles and whether exercise can improve this dysfunction. Adiponectin (adipoQ), a myokine that acts in energy homeostasis and muscle mass regulation, is considered a biomarker of obesity. Studies suggest that exercise can prevent or even reverse obesity by altering the expression of adiponectin in muscles. Various factors such as diet, muscle type, and physical activity intensity appear to influence adipoQ induction. Resistance training emerges as a therapeutic strategy against obesity. Studies indicate an interaction between insulin-like growth factor 1 (IGF-1) and adipoQ in obesity. This project aims to understand this interaction by exploring adiponectin knockout mice, resistance training, and high-fat diet. The results may provide crucial insights for preventive and therapeutic approaches against obesity and its associated complications.