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Effect of intake of chia (Salvia hispanica L.) in the expression of adipokines and metabolic regulators in adipose tissue, skeletal muscle and liver of mice treated with hyperlipidic and hypercaloric diet

Grant number: 13/12410-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Lila Missae Oyama
Grantee:June Carnier
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The obesity is associated with adipose tissue, liver and muscle insulin resistance and a chronic low grade inflammatory process. The adipose tissue depots from the obese secrete proinflammatory adipokines like TNF-±, IL-1 and IL-6, and reduce the production of anti-inflammatory factors as adiponectin and IL-10. The nuclear transcription factor kappa B (NFºB) is one of pathway evolved in the inflammatory response induced by obesity. The activation of this pathway by lipopolysaccharides and saturated fat acid promote a production of inflammatory cytokines and the development of inflammation, insulin resistance leading to metabolic syndrome. Healthy food can control and prevent the metabolic syndrome. In this sense, chia seed (Salvia hispanica L), an oleaginous rich in many nutrients including PUFA, shows an antiinflammatory effect. But studies on the celular mechanisms and possible relation to adipokines and miokines evolved in the effect of chia is sparce. Then, the aim of this study is the treatment with Salvia Hipânica L. on inflammatory mediators and activation of TLR-4 pathway in the white adipose tissue, skeletal muscle and liver, from mouse treated with hyperlipidic and hypercaloric diet.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE MIRANDA, DANIELLE ARAUJO; DA SILVA, FERNANDA PINHEIRO; CARNIER, MARCELA; MENNITTI, LAIS VALES; FIGUEREDO, RAQUEL GALVDO; LOSINSKAS HACHUL, ANA CLAUDIA; BOLDARINE, VALTER TADEU; PINTO NETO, NELSON INACIO; SEELAENDER, MARLLIA; RIBEIRO, ELIANE BERALDI; OILER DO NASCIMENTO, CLAUDIA MARIA; CARNIER, JUNE; OYAMA, LILA MISSAE. Chia flour (Salvia hispanica L.) did not improve the deleterious aspects of hyperlipidic diet ingestion on glucose metabolism, but worsened glycaemia in mice. Food Research International, v. 121, p. 641-647, JUL 2019. Web of Science Citations: 1.
CARNIER, JUNE; SILVA, FERNANDA PINHEIRO; DE MIRANDA, DANIELLE ARAUJO; SANTAMARINA, ALINE BOVETO; MENNITTI, LAIS VALES; MOREIRA, RENATA GUIMARAES; OLLER DO NASCIMENTO, CLAUDIA MARIA; RIBEIRO, ELIANE BERALDI; OYAMA, LILA MISSAE. Chia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in mice. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, v. 119, n. 10 OCT 2017. Web of Science Citations: 1.

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