Analysis of the transcriptional profile of syncytial virus (RSV) at different viral titers

• Grant number: 24/07577-6
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Effective date (Start): August 01, 2024
• Effective date (End): October 29, 2024
• Field of knowledge: Health Sciences - Collective Health
• Principal Investigator: Rejane Maria Tommasini Grotto
• Grantee: Agatha Mayume Silva Kubo
• Supervisor: Lei Gu
• Host Institution: Faculdade de Ciências Agronômicas (FCA). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Research place: Max Planck Society, Bad Nauheim, Germany
• Associated to the scholarship: 23/14446-2 - Analyses of the transcriptional profile of respiratory syncytial virus (RSV) at different viral titrations, BP.IC

Abstract

Respiratory syncytial virus (RSV) is one of the leading causes of severe respiratory diseases in children under 5 years of age. In 2015, RSV was responsible for approximately 3.2 million pediatric hospitalizations worldwide. Moreover, there is no effective medication or vaccine against RSV. Therefore, the goal of this project is to analyse the transcriptome to find the lncRNA that is responsive to the RSV and identify its potential lncRNA-protein interaction networks. The BEAS-2B cell model infected with RSV will be used at different RSV titers to mimic severe and mild infections, to investigate possible associations between lncRNAs and the clinical progression of patients infected with RSV.