Studies to evaluate Alzheimer's disease pathology in transgenic mice after exposure to air pollution

• Grant number: 24/07562-9
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: January 01, 2025
• End date: April 30, 2025
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Giselle Cerchiaro
• Grantee: Augusto Batista Farias
• Supervisor: Masashi Kitazawa
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• Institution abroad: University of California, Irvine (UC Irvine), United States
• Associated to the scholarship: 23/01049-5 - Studies of routes of administration of new copper chelators for use in therapy for Alzheimer's diseasee, BP.IC

Abstract

Addressing Alzheimer's disease (AD) requires a multifaceted approach. Understanding how environmental risk factors like air pollution and changes in the gut microbiome relate to AD is crucial, and it is the current subject from Professor Masashi Kitazawa lab. This subject promises not only insights into the neurotoxic mechanisms of disease progression but also points to potential preventative strategies and treatments. In this FAPESP-Internship program, we propose 4 Month's stay in Prof. Kitazawa lab, working with an in vivo experimental model of AD submitted to conditions such air pollution, studying changes in brain pathologies from these model mice using various techniques including immunostaining, immunoblotting and ELISA. (AU)