PRODUCTION OF MEMBRANES WITH POLYVINYL ALCOHOL CONTAINING CHLORINATED BIOACTIVE GLASS IN ORDER TO IMPROVE OSTEOINDUCTION

• Grant number: 24/22774-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2025
• End date: April 30, 2026
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Ivone Regina de Oliveira
• Grantee: Bianca Lapadula Heckert Franklin de Abreu
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil

Abstract

Periodontitis is a chronic inflammatory disease that can lead to the progressive destruction of the tissues that support the tooth, resulting in severe functional and aesthetic losses. Although guided tissue regeneration techniques are widely used, the membranes available on the market have limited biodegradation and bioactivity, which reduces their effectiveness in bone and periodontal tissue regeneration. In this context, there is an urgent need to develop new materials that combine controlled biodegradation and superior biological performance to meet clinical demands. This project aims to develop advanced barrier membranes for bone and soft tissue regeneration, using the biocompatible polymer poly(vinyl alcohol) (PVA). This polymer will be combined with bioactive compounds, such as hydroxyapatite and chlorinated bioactive glass, which should confer osteogenic and antimicrobial properties. The methodology involves the production of these membranes through a process known as electrospinning, in which polymer and bioactive solutions are carefully prepared to optimize characteristics such as porosity and degradation control. The membranes will be analyzed for their structure, mechanical performance, interaction with cells and ability to prevent infections. Laboratory tests will evaluate cell viability, formation of mineralization nodules and the antimicrobial effect of the membranes. The ultimate goal is to develop materials that offer better functionality, greater integration with body tissues and protection against infections, contributing to significant advances in dental and orthopedic treatments aimed at tissue regeneration.