Diet Quality and Cardiometabolic Risk Parameters in Females

• Grant number: 25/00982-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2025
• End date: May 31, 2026
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Jarlei Fiamoncini
• Grantee: Ana Beatriz Ferreira Gerzoshkowitz
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/02941-6 - Bile acids as determinants of postprandial metabolism and intestinal microbial colonization in newborns, AP.PNGP.PI

Abstract

Changes in dietary patterns, influenced by socioeconomic factors such as urbanization and population aging, and changes in lifestyle such as increased sedentary lifestyle and availability of ultra-processed foods, have contributed to the increase in chronic non-communicable diseases. Balanced diets, such as the Mediterranean diet, offer benefits for metabolic health, while the Western diet, rich in sugars and saturated fats, increases the risk of cardiometabolic disorders. In the case of women, hormonal changes such as menopause negatively influence metabolism, increasing cardiometabolic risk and making it necessary to develop personalized nutritional strategies. This study is part of the study PRIME (Postprandial Regulation of Intermediate Metabolism) and will evaluate at least 150 women between 18 and 70 years old, with BMI of 18.5 to 34.9 kg/m², analyzing blood glucose, plasma concentration of non-esterified fatty acids, triglycerides and total cholesterol after a 10-hour fast. Anthropometric parameters related to body composition will also be assessed, and the volunteers' dietary patterns will be investigated through the application of dietary surveys. Finally, through multivariate statistical analysis, we will assess the relationship between diet and cardiometabolic risk markers, contributing to the development of personalized nutritional strategies. This study will contribute to increasing knowledge about the relationship between diet and women's health. (AU)