STUDY OF THE OSTEOREGENERATIVE POTENTIAL OF SODIUM CALCIUM SILICOPHOSPHATES IN MODEL RABBIT TIBIA (Oryctolagus cuniculus)

• Grant number: 24/20295-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2025
• End date: May 31, 2027
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Bruno Watanabe Minto
• Grantee: Beatriz Maia Galetti
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Despite the existence of modern and efficient techniques for treatingbone fractures in small animals, complication rates persist, keeping this approachchallenging. Numerous adjuvant techniques for fracture healing have been described,among which bioceramics belonging to the sodium calcium silicophosphate familystand out due to their high potential for regenerating bone tissue. This study aims toanalyze the osteoregenerative properties of sodium calcium silicophosphate compositesin the healing of bone fractures. It is hypothetically believed that the sodium calciumsilicophosphate graft would aid and accelerate bone healing. Twenty-four healthy, adultrabbits weighing between 3.30 and 7.70 lb will be used. An established model of a non-critical bone defect in the medial and proximal tibia bilaterally will be used. The lefttibia will have the defect filled with the graft studied, while the contralateral tibia willconsist only of an empty fracture site. Radiographic monitoring will be carried out ondays 1, 15, 30, 60, 90 and 120 after graft placement. Histomorphometric analysis will becarried out at the end of the study period. These analyses will make it possible to assessthe osteoregenerative potential and biocompatibility of the sodium calciumsilicophosphate bioceramic composites studied. The results obtained will make itpossible to prove or disprove the hypotheses put forward, which will provide valuableinformation on the effectiveness of the material for clinical application in bonefractures. (AU)