Co-circulation and co-infection of human respiratory syncytial virus and human metapneumovirus in children treated in 2007 at the University Hospital of the University of São Paulo, city of São Paulo

• Grant number: 07/00235-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2007
• End date: October 31, 2008
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Edison Luiz Durigon
• Grantee: Larissa Cuba Lins Carvalho
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Respiratory tract infections are a major cause of morbidity and mortality. The World Health Organization ranks respiratory diseases as the second-leading cause of death worldwide in children younger than 5 years. Human Metapneumovirus (HMPV) and the Respiratory Syncytial Virus (HRSV) are a paramyxovirus associate with respiratory illness. Data from that report suggest that HMPV and HRSV have similar symptoms and occurs during winter months and is common during childhood. Our study will be based on nucleic acid amplification using the technic RT-PCR-GeneScan. A reverse transcription polymerase chain reaction (RT-PCR) assay based on automated fluorescent capillary electrophoresis and GeneScan software analysis can developed to detect eight common respiratory viruses in clinical specimens from young children. The aims of the present study will to show the co-infection and co-circulation about the virus HMPV and HRSV from children admitted to the University Hospital (HU-Sao Paulo/Basil) with an acute respiratory tract infection diagnosis in 2007.