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Functional characterization of genes from the pathogenic fungus Trichophyton rubrum during interaction with host microenvironment cells and molecules

Grant number: 09/08411-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2009
Effective date (End): September 30, 2012
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Nilce Maria Martinez-Rossi
Grantee:Nalu Teixeira de Aguiar Peres
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


In the last decades there was an increase in the incidence of fungal infections, caused by the high number of immunocompromised patients, leading to a necessity of understanding the mechanisms involved in the pathogenesis of these infections. The definition of the global gene expression and characterization of the molecules required for fungal nutrient acquisition and stress response caused by the host defense mechanisms allows a better knowledge about the strategies used by the pathogens during infection. Transcription analyses of the pathogenic fungus Trichophyton rubrum, a dermatophyte highly prevalent in clinical cases of human nail and skin infections, performed by our research group, allowed the identification of several genes involved in its interaction with host cells and molecules, and in response to cytotoxic agents. The proposal of this project is to continue these experiments, evaluating the functional role of genes potentially involved with this dermatophyte pathogenicity by post transcriptional silencing RNA (interference RNA) or gene disruption by homologous recombination. The functional characterization of these genes and their role during infection of skin and nail will provide a better comprehension about the molecular traits used by T. rubrum during infection of the host, and may also reveal novel cellular targets for the development of new antifungal drugs.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE AGUIAR PERES, NALU TEIXEIRA; DA SILVA, LARISSA GOMES; SANTOS, RODRIGO DA SILVA; JACOB, TIAGO RINALDI; PERSINOTI, GABRIELA FELIX; ROCHA, LENALDO BRANCO; FALCAO, JULIANA PFRIMER; ROSSI, ANTONIO; MARTINEZ-ROSSI, NILCE MARIA. In vitro and ex vivo infection models help assess the molecular aspects of the interaction of Trichophyton rubrum with the host milieu. Medical Mycology, v. 54, n. 4, p. 420-427, MAY 2016. Web of Science Citations: 12.
MARTINEZ-ROSSI, NILCE M.; JACOB, TIAGO R.; SANCHES, PABLO R.; PERES, NALU T. A.; LANG, ELZA A. S.; MARTINS, MAIRA P.; ROSSI, ANTONIO. Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives. CURRENT GENOMICS, v. 17, n. 2, p. 99-111, 2016. Web of Science Citations: 7.
JACOB, TIAGOR.; PERES, NALUT. A.; MARTINS, MAIRA P.; LANG, ELZA. S.; SANCHES, PABLO R.; ROSSI, ANTONIO; MARTINEZ-ROSSI, NILCE M. Heat Shock Protein 90 (Hsp90) as a Molecular Target for the Development of Novel Drugs Against the Dermatophyte Trichophyton rubrum. FRONTIERS IN MICROBIOLOGY, v. 6, NOV 10 2015. Web of Science Citations: 15.

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