A new approach for dihydro-isoquinolinones and tetra-isoquinolines preparation from Morita-Baylis-Hillman adducts

• Grant number: 06/04767-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2006
• End date: November 30, 2007
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Michele Fernanda Lino de Souza
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project for an undergraduate student has as proposal the preparation of dihydroisoquinolinones and tetrahydroisoquinolines from Morita-Baylis-Hillman adducts using a new synthethic approach. This approach is based on the utilization of a ozonolyis reaction of the silylated adducts, followed by a reductive amination step. (AU)