Angiogenesis markers in patients with preeeclampsia

• Grant number: 10/08082-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2010
• End date: September 30, 2011
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Silvia Daher
• Grantee: Patricia Akie Akita
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality. Placental angiogenesis stands out as one of the most important mechanisms involved in the physiopathology of PE. Disturbances in the production of pro and anti-angiogenic mediators may cause endothelial lesion, leading to hypertension and proteinuria, the typical manifestations of PE. Adiponectin and soluble endoglin (sEng) seem to play a critical role in this context. Adiponectin is produced by adipocytes and exerts a proangiogenic effect on endothelium. On the other hand, soluble endoglin exerts an anti-angiogenic effect by blocking the endothelial vasodilatation mediated by nitric oxide (NO). Patients with PE have hypoperfused placentas, which may be related to changes in the levels of these proteins. A large number of factors have been examined and although there are controversies, evidence indicates that the combined assessment of pro-and anti-angiogenic factors would better reflect the degree of vascular compromise. Based on these premises, we aimed to assess adiponectin (pro-angiogenic) and sEng (anti-angiogenic) serum levels in patients with PE compared to healthy women of the same gestational age.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TOBINAGA, CLARISSA M.; TORLONI, MARIA R.; GUEUVOGHLANIAN-SILVA, BARBARA Y.; PENDELOSKI, KAREN P. T.; AKITA, PATRICIA A.; SASS, NELSON; DAHER, SILVIA. Angiogenic factors and uterine Doppler velocimetry in early- and late- onset preeclampsia. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, v. 93, n. 5, p. 469-476, MAY 2014. (10/08082-8, 09/54729-6)