Study on mitochondria-nucleus regulatory and communication ways in controlling co-expression of Saccharomyces cerevisiae respiratory complexes

• Grant number: 08/06757-8
• Support Opportunities: Scholarships abroad - Research
• Start date: November 10, 2008
• End date: April 09, 2009
• Field of knowledge: Biological Sciences - Biochemistry - Biochemistry of Microorganisms
• Principal Investigator: Mario Henrique de Barros
• Grantee: Mario Henrique de Barros
• Host Investigator: Alexander Tzagoloff
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Columbia University in the City of New York, United States

Abstract

Mitochondria and nucleus crosstalk is continuous and regulated by a number of gene products and secondary metabolites. External signals are also detected by different pathways, leading to a differential expression of genes involved in the respiratory electron chain. Mitochondrial dysfunction and metabolites generated by its Redox state are also detected by nucleus receptors, resulting in a secondary control of gene expression. Our proposal here is to identify the cause of a respiratory deficiency caused by a gene allele involved in general transcription repression - SSN6, and also finish the studies with the ORF YGR102, involved in the co-expression of two different respiratory complexes: cytochrome c oxidase and ATP sintase. (AU)