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| Author(s): |
Bianca Balbino
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-12-02 |
| Examining board members: |
Momtchilo Russo;
Alexandre Salgado Basso;
Ana Maria Caetano de Faria
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| Advisor: | Momtchilo Russo |
| Abstract | |
Tolerance is among the Immunology pillars. Experimental data indicate that tolerance towards an antigen can promote tolerance to an unrelated antigen, a phenomenon known as cross-tolerance. Here we sought to characterize cross tolerance using OVA as a tolerogen and Blomia tropicalis (Bt) extract or Keyhole limpet Hemocianina (KLH) as allergens. We found that cross tolerance can be reproduced in the model of allergic lung disease induced by KLH or Bt, with less inflammatory infiltrate in the lung, eosinophils, total IgE and mucus production. Using cross tolerance therapeutically, i.e., after KLH sensitization, was not effective, since the allergic lung response was not modulated. Altogether, our data shows that OVA tolerance modulate allergic lung disease induced either by Bt or KLH when used as prophylactic model, however cross tolerance is ineffective in sensitized animals. (AU) | |
| FAPESP's process: | 12/09977-4 - Cross tolerance in experimental ashtma model induced by Blomia tropicalis |
| Grantee: | Bianca Balbino |
| Support Opportunities: | Scholarships in Brazil - Master |