Involvement of CD200 in the infectivity of Leishmania (Leishmania) amazonenses isolates associated with localized cutaneous leishmaniasis and diffuse cutaneous leishmaniasis.

Author(s)

Lina Borda Samper

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2015-11-19

Examining board members

Mauro Javier Cortez Véliz; Luis Carlos Crocco Afonso; Danilo Ciccone Miguel

• Advisor: Mauro Javier Cortez Véliz

Abstract

Leishmania (Leishmania) amazonenses is one of the etiologic agents of two forms of leishmaniasis: diffuse (DCL) and localized (LCL) cutaneous leishmaniasis. LCL is presents a unique ulcerated lesion and DCL multiple non-ulcerative nodules. Until now, it is not well known which factors influence the development of LCL or DCL. The parasites virulence has been associated with the ability to survive inside the activated macrophage. CD200 is a glycoprotein that interacts with CD200R inhibiting the proinflammatory response of the cell. Recently it was revealed during the infection process in macrophages L. (L.) amazonenses enhances CD200 expression in the early stages of infection resulting in the intracellular survival of amastigotes. The aim of this study was to determine the association between the induction of CD200 during infection with L. (L.) amazonenses isolates associated with LCL or DCL. An increase in CD200 expression was noteworthy in the late stages of infection, which was also related to a higher infectivity rate of L. (L.) amazonenses isolates. (AU)

• FAPESP's process: 13/15254-8 - Involvement of CD200 in the infection of L. (L.) amazonensis isolates associated to cutaneous Leishmaniasis (LCL) and Difuse cutaneous Leishmaniasis (DCL)
• Grantee: Lina Borda Samper
• Support Opportunities: Scholarships in Brazil - Master