Nasal symptoms, hemodynamic parameters and nasal and systemic inflammatory profile of sugarcane cutters exposed to biomass burning

Author(s)

Iara Buriola Trevisan

• Document type: Master's Dissertation
• Press: Presidente Prudente. 2016-02-12.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente
• Defense date: 2016-01-26
• Advisor: Dionei Ramos

Abstract

Introduction: The harvest of sugarcane preceded by night burning exposes workers to high concentrations of pollutants added to the effects of the workday causes increased cardiorespiratory work, causing alterations multisystem. Despite the great evidences of the deleterious effects of exposure to particulate matter (PM), still has been given little attention to the effects of long-term occupational exposures. Objective: This Master’s thesis aimed to evaluated nasal symptoms, hemodynamic parameters and nasal and systemic inflammatory profile of sugarcane cutters exposed to biomass burning along a sugarcane harvest. Methods: Were evaluated in article I 41 individuals and in article II 45 individuals, sugarcane cutters, male cutters from a sugar and alcohol plant divided into groups according to smoking habit. To evaluate the frequency and intensity nasal symptoms was questionnaire applied of respiratory symptoms and to evaluate the hemodynamic parameters was registered blood pressure (BP), heart rate (HR) and respiratory (f). For analysis of the nasal inflammatory profile (IL-6, IL-10 and IL-4) was collected nasal lavage and for analysis of the systemic inflammatory profile (TNF-α, IL-6, IL-8 and IL-10) and total count monocytes and neutrophils from venous blood were performed. The evaluations occurred during the pre-harvest (March), middle of harvest (July) and end of harvest (October) in 2014. Results: During the middle of harvest there was a significant increase in the frequency and intensity of symptoms sneezing, nasal congestion beyond the increase in reports of difficulty in breathing. In relation the BP, HR and RR all participants showed significant alterations during the harvest. For analysis of inflammatory profile there were significant changes in systemic levels for IL-8 and neutrophil counts that had an increase in middle of harvest followed by a decrease at the end of harvest. Conclusions: Conclude that sugarcane cutters have increased in frequency and intensity of nasal symptoms, as well as changes in hemodynamic parameters, mainly in the middle of harvest. In addition, all cutters showed a decrease in IL-8 and neutrophil counts at systemic level at the end of harvest due to repeated exposure to PM. (AU)

• FAPESP's process: 14/08029-0 - ANALYSIS OF NASAL AND SYSTEMIC INFLAMMATION REACTION IN SUGARCANE CUTTERS SUBJECT TO SEVERE PHYSICAL ACTIVITY AND EXPOSURE TO AIR POLLUTION
• Grantee: Iara Buriola Trevisan
• Support Opportunities: Scholarships in Brazil - Master