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| Author(s): |
Daniel de Oliveira Martins
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2016-05-16 |
| Examining board members: |
Marucia Chacur;
Soraia Kátia Pereira Costa;
Joao Gualberto de Cerqueira Luz;
Rodrigo Alvaro Brandão Lopes Martins;
Silvia Regina Dowgan Tesseroli de Siqueira
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| Advisor: | Marucia Chacur |
| Abstract | |
The inferior alveolar nerve injury (IAN) is related to dental practice. Studies have shown that LLLT promotes nerve regeneration and analgesia. Using IAN crush model associated with laser therapy we evaluated nerve repair and nociception of animals before injury and after treatment. We have seen that the laser reversed hipernociceptive behavior and modulation of glutamate receptors, neurotrophins, the transient potential vanilloid receptor subtype 1, substance P and calcitonin gene-related peptide act in this process. Additionally, the laser alter the microenvironment of the lesion modulating proteins such as laminin, myelin protein zero and neurofilaments, promoting nerve regeneration; electron microscopy showed this regeneration, evidenced by the increase in the number of nerve fibers and the thickness of the myelin sheath in nerve treated group compared to the surgery group. Together, these results contribute to enhance the therapeutic use of the laser. (AU) | |
| FAPESP's process: | 10/20026-6 - Use of low-level laser and mechanisms in molecular and cellular repair process in peripheral nervous system |
| Grantee: | Daniel de Oliveira Martins |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |