Participation of Mollicutes and genital interest microrganisms on human endometriosis.

Author(s)

Guilherme Barreto Campos

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-09-14

Examining board members

Jorge Timenetsky; Caio Mauricio Mendes de Cordova; Ana Marcia de Sá Guimarães; Ana Paula Lepique; Antonio Carlos Campos Pignatari

• Advisor: Jorge Timenetsky; Mauricio Simões Abrão

Abstract

Endometriosis is a disease characterized by the presence of endometrium outside of uterus. This study aimed to detect Mollicutes (M. genitalium, M. hominis, U. urealyticum and U. parvum), HPV and N. gonorrhoeae in samples of endocervical swab, peritoneal fluid and biopsied tissue from women with (case group) and without endometriosis (control group) and evaluate the finds with endometriosis. In swab samples the prevalence of M. hominis (Mh), M. genitalium (Mg), U. urealyticum (Uu) and HPV were higher in case group (43.7%, 14.1%, 8.5% e 5.9% respectively) than the control group. In the peritoneal fluid it was higher in the case group as well (Mh: 27.8%; Mg: 40.7%; Uu: 3.7% e HPV: 9.6%).In the biopsied tissue, Mh (5.9%) and Mg (13.2%) were higher in the case group. M. genitalium in the peritoneal fluid was associated to a higher production of IFN-γ and IL-1β. Downregulation of inflammatory genes were accentuated when M. genitalium was detected. Upregulation occurred when M. hominis was detected. Mollicutes could influence in the immune response on endometriosis. (AU)

• FAPESP's process: 14/12009-5 - Evaluation of mollicutes and other genital microorganisms participation in human endometriosis
• Grantee: Guilherme Barreto Campos
• Support Opportunities: Scholarships in Brazil - Doctorate