Exercise training: a safe and effective strategy for reducing inflammation in cachectic cancer patients.

Author(s)

Emídio Marques de Matos Neto

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-10-10

Examining board members

Marilia Cerqueira Leite Seelaender; Miriam Helena Fonseca Alaniz; Alison Colquhoun; Claudia Maria da Penha Oller do Nascimento; Jose Pinhata Otoch

• Advisor: Marilia Cerqueira Leite Seelaender

Abstract

Cancer cachexia is a multifactorial and multiorgan systemic syndrome with an unknown aetiology and characterized by a profound weight loss. Therefore, this study aimed to investigate the inflammation process in a systemic context and in the subcutaneous adipose tissue (SAT) and to evaluated the possible anti-inflammatory effects of the aerobic exercise in subjects with cancer cachexia. Patients were separated in six groups: Control (sedentary SED and trained TR), weight-stable patients with gastrointestinal cancer (WSC SED and TR) and patients with gastrointestinal cancer and cachexia (CC SED and TR). Cessation of weight loss and cardiorespiratory gain wre observed in the CCTR group and a reduction of total cholesterol in the CCTR group decreased in LDL in the CC SED group and HDL in the CC SED and CC TR groups. Physical exercise was able to increase serum HDL during the intervention. No differences were found in the immune cells infiltrating in the patients sAT (macrophages and MDSC). Inflammatory mediators changed by cachexia were modulated by ET. To our knowledge, this is the first study to demonstrate a reduction of inflammation and cachexia symptoms in cancer patients. (AU)

• FAPESP's process: 12/10129-8 - Inflammation in the adipose tissue of patients with cancer cachexia: exercise training as a therapeutic strategy.
• Grantee: Emidio Marques de Matos Neto
• Support Opportunities: Scholarships in Brazil - Doctorate