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| Author(s): |
Gabriela de Mello Miassi
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Botucatu. 2016-08-30. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu |
| Defense date: | 2016-08-19 |
| Advisor: | Dirlei Antonio Berto; Marcos Livio Panhoza Tse |
| Abstract | |
This study was conducted to evaluate effects of dietary supplementation of nucleotide (disodium 5´guanylate and disodium 5´inosinate) on the growth performance, relative weight and carbon turnover 13C of the small intestine, spleen, liver and pancreas of weaned piglets of 21 days of age. The treatments were dietary supplementation with 0% (control); 0.2%; 0.4% or 0.6% nucleotide of diet. In the first trial eighty-four weaned piglets (6.04 ± 0.25 kg average initial BW) were allotted to four dietary treatments (Nu levels) with seven pens per treatment and three pigs per pen, in a randomized complete block design to evaluate the performance. In the second trial eighty-seven weaned piglets (6.03 ± 0.23 kg average initial BW) were used in a randomized complete block design, with the same treatments, and on the day of weaning (day zero) were slaughtered three piglets and days 3, 5, 8, 12, 23, 35 and 49 after weaning, three pigs per treatment were slaughtered, to evaluate the effect of nucleotide on the turnover 13C in the mucosa and intestinal wall (duodenum and jejunum), spleen, liver and pancreas and relative weight of the small intestine and spleen, liver and pancreas. During the first period (21 to 36 days of age), no differences were detected on the performance. During the second period (21 to 48 days of age), a quadratic effect (P < 0.01) of the levels of nucleotide was verified on average daily feed intake and average daily weight gain. During the whole experimental period (21 to 55 days of age), there was a quadratic effect of the levels of nucleotide (P < 0.01) on average daily weight gain. In the second experiment were observed decrease half-life to the duodenum mucosal and wall in treatment 0.4% Nu and jejunum mucosa and wall in treatment 0.2% Nu and 12th day of slaughter there was a linear effect (P < 0.01) of Nu levels relative weight of the small intestine. The values of carbon half-life to the spleen were 19.5; 18.1; 18.4 and 17.1, to the liver were 10.4; 10.1; 10.1 and 11.3 day, to the pancreas were 17.2; 14.6; 13.8 and 15.4 day, respectively, for the piglets fed 0,0%; 0.2%; 0.4% and 0,6% de Nu, respectively. Lower values of half-life was observed to the spleen, liver and pancreas of animal were dietary supplementation with 0.6%, 0.2% and 0.4% Nu, respectively. The nucleotide supplementation in the diets of pigs improves performance and accelerates the carbon turnover of mucosa and intestinal wall, in the spleen, liver and pancreas suggesting a faster recovery and growth in the post-weaned period. (AU) | |
| FAPESP's process: | 13/17964-2 - Performance, blood lipid profile and turnover of carbon (´13c) in tissues of weanling pigs fed diets containing nucleotides. |
| Grantee: | Gabriela de Mello Miassi |
| Support Opportunities: | Scholarships in Brazil - Doctorate |