Caprine demineralized bone matrix (MODc) in the repair of non-critical bone defects in rabbit tibia

Author(s)

Felipe Rocha dos Santos

• Document type: Master's Dissertation
• Press: Jaboticabal. 2019-03-18.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal
• Defense date: 2019-02-26
• Advisor: Bruno Watanabe Minto

Abstract

The objective of this study was to evaluate the demineralized goat bone matrix as xenograft in tibial bone defects of rabbits. Twenty-four female rabbits, New Zealand adults, were used. A circular monocortical defect of 6 mm in diameter was created in the form of tibias, without proximal third of the medial surface. The case of the boundary case of the case of the demineralized caprine, while a corresponding right to control. On the postoperative days of 15, 30, 60 and 90 days, the six animals were submitted to euthanasia and proximal tibia samples were collected. The samples were scanned by computerized helical microtomography. Analyzed as macroscopic of bone repair, trabecular filling pattern and intralesional bone formation. Statistically significant differences were observed between the groups, so that the volumes were adjusted to the variable between volume and total volume at times 15, 30 and 90 days, with higher bone production in the control group. It was also evidenced the statistical superiority of the control group in relation to the set of matrices, such as the temperature in bone ground, the relation between the bone surface and the total surface and the number of trabeculae, in the 15 and 90 days, control. The demineralized bone matrix demonstrated to be biotolerable and safe in systems, during 90 days, proved by computer microtomography, the beginning of the system installation in 30 days after implantation, as well as a bone bridge formation at 60 days. (AU)

• FAPESP's process: 17/09563-9 - Micro-CT evaluation of caprine demineralized bone matrix (MOD) on bone healing in rabbits
• Grantee: Felipe Rocha dos Santos
• Support Opportunities: Scholarships in Brazil - Master