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| Author(s): |
Annalú Pinton Ferreira
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Botucatu. 2019-06-28. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu |
| Defense date: | 2019-05-08 |
| Advisor: | Cláudia Valéria Seullner Brandão |
| Abstract | |
Platelet rich plasma (PRP) acts on corneal repair and, when heated, presents reduced local immune response without interfering in growth factor levels. This clinical trial aimed to compare the use of autologous PRP (AP) and heated allogeneic PRP (HP) in the treatment of ulcerative keratitis in dogs, as well as their clinical effects. For this purpose, 24 dogs were utilized from the routine with diagnosis of ulcerative keratitis, and randomly distributed into two experimental groups, one treated with autologous PRP eye drops (n=11) and the other with heated allogeneic PRP eye drops (n=13). All the animals were evaluated at the initial moment of attendance and after 3, 5, 10, 15 and 30 days of treatment. The ophthalmologic variables analyzed were: blepharospasm, ocular discharge, corneal opacity, vascularization, photophobia, conjunctival hyperemia, chemosis, corneal thickness, as well as the percentage of corneal ulcer reduction. There were no statistical differences between the groups as to the treatment utilized whereas there was verification of a reduction in the injury-wound-healing time with adequate corneal re-epithelialization, as well as diminution of opacity and of inflammation signs. It was concluded that autologous and heated allogenic PRP in dogs are comparable in efficacy and constitute an excellent option in the adjuvant treatment of ulcerative keratitis. (AU) | |
| FAPESP's process: | 17/13836-0 - The use of autologous platelet-rich plasma and heated allogeneic in the treatment of ulcerative keratitis in dogs |
| Grantee: | Annalú Pinton Ferreira |
| Support Opportunities: | Scholarships in Brazil - Master |