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| Author(s): |
Renata Alves da Silva
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) |
| Defense date: | 2011-03-25 |
| Examining board members: |
Massuo Jorge Kato;
Joao Pedro Simon Farah;
Dulce Helena Siqueira Silva
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| Advisor: | Massuo Jorge Kato |
| Abstract | |
The phytochemical study of extracts from adult plants and seedlings of the species Piper reticulatum, collected in the Carajás National Forest, afforded the isolation of four amides, including dihydrowisanidine, previously described from this species, wisanidine, (2E,4E)-N-2-isobutyleicosa-2,4-dienamide, (3E,5E,14E)-N-3,5,14-pyrrolidyleicosa-trienamide (novel based on the unsaturations position at the alkyl chain), a lignan (syringaresinol) and a nitrile (cianobenzyl benzoate) and, additionaly eigh amides containing long alkyl chain had their structures proposed based on gas and liquid chromatography coupled to mass spectrometry data. The extracts and the isolated natural products were evaluated for their potential antifungal activity against the phytopathogens Cladosporium cladosporioides and C. sphaerospermum and acetylcholinesterase inhibitory activity, being found strong activity for amides for both two tests, and strong activity for nitrile against C. sphaerospermum. In addition, extracts of adult plants and seedlings of P. reticulatum were analyzed by MS (ESI +) and by PCA (principal component analysis) and HCA (hierarchical cluster analysis) together with the species P. amalago, phylogenetically related to P. reticulatum, P. crassinervium, P. solmsianum, P. fuligineum, P. gaudichaudianum, P. aduncum and P. tuberculatum in order to distinguish or classify them according to the metabolic profile. (AU) | |
| FAPESP's process: | 08/51674-3 - Secondary metabolites of Piper reticulatum L. |
| Grantee: | Renata Alves da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |