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| Author(s): |
Marilia Farignoli Romeiro
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Ribeirão Preto. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) |
| Defense date: | 2019-10-03 |
| Examining board members: |
Luiz Tadeu Moraes Figueiredo;
Emiliana Pereira Abrão da Costa
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| Advisor: | Luiz Tadeu Moraes Figueiredo |
| Abstract | |
The first blood banks in Brazil were founded in 1941. With the discovery of the Human Immunodeficiency Virus (HIV) and especially since 1988, donors have been registered and blood treated for some pathogens. However, arboviruses such as Dengue fever, already described in cases of transfusional transmission, are not checked for in donors, and with the emergence of Zika and Chikungunya viruses this risk has become even greater. The present work, carried out in 2017 and 2018, studies infections with Alphavirus e Flavivirus in blood donors in the city of São Carlos, SP. Plasmas of 5,608 blood donors were analyzed for the genomes of these viruses and antibodies, as well as neutralization tests. 4 donors were found to be infected with Zika virus representing a risk of viral transmission to recipients of their blood products. Eight donors had CHIKVspecific IgM antibodies showing that in a recent previous period, in which some cases occurred in the community, donors would have offered a risk of transmission to recipients of their blood products. The occurrence of 36 IgM-positive donors for Mayaro virus and 11 others with specific neutralizing antibodies suggests that in a recent past, these individuals have become infected with this virus at risk of transmission to recipients of their blood products. The unprecedented serological diagnosis of infections by Mayaro in blood donors shows that this virus must have circulated, or must be circulating, inadvertently, in the state of São Paulo, causing human infection, which requires the attention of the Public Health System. (AU) | |
| FAPESP's process: | 14/20851-8 - Study about Alphavirus and Flavivirus infections in samples of blood bank |
| Grantee: | Marilia Farignoli Romeiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |