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| Author(s): |
Wesley Leoricy Marques
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-02-12 |
| Examining board members: |
Andreas Karoly Gombert;
Adriano Rodrigues Azzoni;
Mário Henrique de Barros
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| Advisor: | Andreas Karoly Gombert |
| Abstract | |
The biotechs industry is a growing field since fossil resources are being attached to ecological and geopolitical constraints. In this scenario, Brazil has a major role due to its large experience in the bioethanol industry and sugarcane use as a cheap feedstock. The aim of this work is to optimize Saccharomyces cerevisiae allowing them to occupy a new niche: the production of economically valuable chemicals that require cellular free energy (ATP) on their biosynthesis. In this context, heterologous protein expression and evolutionary engineering were done. Therefore, this work will potentially contribute to make certain energy demanding chemicals production economically viable. (AU) | |
| FAPESP's process: | 12/05548-1 - Metabolic engineering of Saccharomyces cerevisiae aimed at improving the energetic yield of sucrose metabolism |
| Grantee: | Wesley Leoricy Marques |
| Support Opportunities: | Scholarships in Brazil - Master |