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| Author(s): |
Evilin Naname Komegae
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-12-11 |
| Examining board members: |
Carla Lima da Silva;
Mônica Valdyrce dos Anjos Lopes Ferreira;
Soniza Vieira Alves Leon;
Caden Souccar;
Sandra Coccuzzo Sampaio Vessoni
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| Advisor: | Carla Lima da Silva |
| Abstract | |
Given the lack of effective treatments for multiple sclerosis (MS) and knowing that venomous have been used as prototype for the development of new drugs here we evaluated the effect of the Tnp, a described antiinflammatory cyclic peptide identified in the venom of Thalassophryne nattereri, on experimental autoimmune encephalomyelitis (EAE), a representative model of MS. We found that distinct treatments of Tnp by mechanisms also dependent on IL-10 significantly reduced the clinical severity of EAE. Tnp was related with: suppression of the activation state of conventional DC and the emergence of plasmacytoid DC; blocking the leukocyte infiltration and the reactivation of Th1, Th17, microglia cells and macrophages in the CNS; increasing of regulatory cells and also Tnp can overcome the BBB and reach the target organ. Tnp can reduce the severity of symptoms and delay the peak of onset of severe symptoms. These results shed light on the role of Tnp a small molecule in the regulation of inflammation and provides a new therapeutic opportunity for the treatment of MS. (AU) | |