Design and synthesis of potential chiral ligands

Author(s)

Marcio Hayashi

• Document type: Master's Dissertation
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Instituto de Química
• Defense date: 2021-02-24

Examining board members

Caio Costa Oliveira; Cristiane Storck Schwalm; Ronaldo Aloise Pilli

• Advisor: Caio Costa Oliveira

Abstract

This work describes the efforts for rational design and synthesis of potential chiral ligands. In the first part, studies aiming the synthesis of chiral n6 ligands were carried out, involving synthetic strategies such as: enantioselective Friedel-Crafts alkylation, HWE reaction, copper (I) catalyzed conjugate addition, Sonogashira reaction and Diels-Alder cycloaddition. However, these aforementioned strategies were unsuccessful, thus hampering the initial plans. For the second part, the rational design and the synthesis of potencial ligand derived from 8-aryl-quinoline were carried out, using a Suzuki-Miyaura reaction as a key step. The potential ligand was obtained in racemic way in 4 steps, opening the door to the development of new catalytically active chiral complexes (AU)

• FAPESP's process: 18/18490-8 - New chiral ruthenium complexes and their applications in asymmetric catalysis
• Grantee: Marcio Hayashi
• Support Opportunities: Scholarships in Brazil - Master