Advanced search
Start date
Betweenand


Assessment of metabolic, oxidative, and anthropometric profiles in women with breast cancer

Full text
Author(s):
Bruna Ramos da Silva
Total Authors: 1
Document type: Doctoral Thesis
Press: Ribeirão Preto.
Institution: Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC)
Defense date:
Examining board members:
Alceu Afonso Jordao Junior; Camila Cremonezi Japur; Sara Maria Moreira Lima Verde
Advisor: Alceu Afonso Jordao Junior
Abstract

Objective: To evaluate the impact of chemotherapy in the nutritional, metabolic and oxidative profile and compare the results to a control group. Methods: A prospective study with women starting chemotherapy with no prior chemotherapy treatment. The control group consisted of women with no history of cancer or chemotherapy treatment. Quality of life (QL) through the EORTC QLQ-BR23 questionnaire, dietary intake by the 24-hour recall, level of fatigue, bioelectrical impedance, physical performance tests, and blood sample for biochemical and oxidative analysis were collected in two-time points: diagnosis (T0) and one month after completion of therapy (T1), for patients with breast cancer (BC) and a single assessment for the control group. Mean, standard deviation, linear regression and ANOVA in SAS Studio were used. Results: 61 women with BC and 59 controls were included. No changes in body composition and dietary intake were found. Still, at T1, patients with BC had worsening fatigue, quality of life, nutritional status, PhA, serum lipids, inflammation, albumin, visceral adiposity (VAI), and around 70% of the sample developed metabolic syndrome. Compared to the control, although they showed similarities in body mass index (BMI), body composition and age, women with BC had worse results in all health markers and worse dietary intake. PhA was significantly correlated with NRI, gait speed test, handgrip test, DPPH, serum retinol and glutathione peroxidase. Conclusion: We found evidence that chemotherapy treatment worsened prognostic factors, such as PhA and nutritional risk and metabolic alterations, without body weight, fat mass, and food intake changes. Despite the high prevalence of obesity in the sample, a significant level of nutritional risk was also observed, reinforcing the need for nutritional counselling independent of weight loss. Compared to controls, patients with BC also have worse metabolic, nutritional, and dietary characteristics. Our results show that PhA is an easy, affordable, and accessible tool correlated with NRI, markers of physical functionality and serum antioxidants in BC patients, regardless of age or BMI. (AU)

FAPESP's process: 17/07963-0 - Evaluation of the metabolic, oxidative and anthropometric profile in women with Breast Cancer
Grantee:Bruna Ramos da Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)