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Role of Insulin Growth Factor 1 (IGF-1) on body composition, oxidative stress, type of tumor and survival in women with Breast Cancer

Grant number: 18/18739-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2023
Field of knowledge:Health Sciences - Nutrition
Principal researcher:Nágila Raquel Teixeira Damasceno
Grantee:Isabelle Romero Novelli
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Breast Cancer is the second most prevalent Cancer in the world and second lead cause of death among this population. The etiology of this Neoplasia is multifactorial, involving environmental and/or hereditary factors. Of all new cases of Cancer in Brazil in 2012, 3.8% were related with high Body Mass Index (BMI) and it was observed a positive association between mortality and BMI. Obesity increases the risk of developing Breast Cancer, alter adipokines levels produced in the adipose tissue and is related with an increase of the oxidative stress and modifications in the IGF-1 system. A greater level of IGF-1 in the plasma is correlated with a risk of developing Breast Cancer. In rats, when the IGF-1 production is suppressed it slows tumor growth. The goal of this project is to evaluate the role IGF-1 system and Obesity in relapse and survival rate of women with Breast Cancer. Until this moment there is no study that propose the hypothesis that women with Breast Cancer have a greater level of plasma IGF-1 regarding their matched controlled pairs and that can lead to greater relapse and survival rate in the studied population. The research project is part of the project "Obesity and Breast Cancer: assessment of risk factors associated with overweight and adipose tissue" approved by the Research Ethics Committee of the General Hospital of Fortaleza (n° 050507/10) and School of Public Health/University of São Paulo (n° 2162). All of the statistical tests will be performed with the program Statistical Package for the Social Sciences® (SPSS), version 20.0 (SPSS Incorporation, 2010). The level of significance considered will be p<0,05. (AU)