Role of the chronic treatment with apocynin on the nitric oxide bioavailability and the reactive oxygen species generation in spontaneously hypertensive rats

Author(s)

Murilo Eduardo Graton

• Document type: Doctoral Thesis
• Press: Araçatuba. 2022-10-21.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba
• Defense date: 2022-04-06
• Advisor: Cristina Antoniali Silva

Abstract

NAD(P)H oxidases (NOX) enzymes are the major source of reactive oxygen species (ROS) in the cardiovascular system. The overproduction of ROS associated to the reduction of the antioxidant capacity lead to oxidative stress, which may cause hypertension, major risk factor for cardiovascular diseases which are the leading causes of death worldwide. Due to this importance, new therapeutical tools and approaches are need to control the development of hypertension and its complications. In the first part of this study, the effects of the chronic treatment with apocynin in spontaneously hypertensive rats (SHR) were evaluated on the nitrix oxide (NO) production and on the generation of ROS, as well the elimination of these species by the antioxidant systems. In the second part, the antioxidant and NOX inhibitory properties of apocynin were evaluated and compared to another potential therapeutical candidate, protocatechuic acid. Both studies suggest the potential use of apocynin as new candidate for the treatment of cardiovascular diseases where oxidative stress play an important role as therapeutical target. (AU)

• FAPESP's process: 17/18436-0 - Study of the post-translational mechanisms involved on increased nitric oxide bioavailability in spotaneoulsy hypertensive rats treated with apocynin
• Grantee: Murilo Eduardo Graton
• Support Opportunities: Scholarships in Brazil - Doctorate