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| Author(s): |
Sandro Carvalho Kusano
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba |
| Defense date: | 2011-06-21 |
| Examining board members: |
Livia Maria Andaló Tenuta;
Carolina Patrícia Aires;
Luis Alexandre Maffei Sartini Paulillo
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| Advisor: | Livia Maria Andaló Tenuta |
| Abstract | |
Fluoride (F) interferes with dental caries development when present in oral environment, reducing dental demineralization and enhancing its remineralization. Although both mechanisms are related to the reduction of mineral loss in the presence of F, no experimental study which evaluated the relative importance of each mechanism on the inhibition of development of dental caries was found. Thus, this in situ, crossover and blind study was performed to evaluate the effect of the period of F dentifrice use, i.e., either before or after daily cariogenic challenges (to simulate either the effect on the reduction of demineralization or on the enhancement of remineralization, respectively), on enamel and root dentin remineralization. Twelve volunteers wore palatal appliances containing three sound enamel slabs and three sound root dentin slabs, with surface hardness previously determined, during three phases of 14 days each. Dental slabs were fixed 1 mm underneath the level of the appliance and covered by a plastic mesh to allow dental biofilm accumulation, and exposed to sucrose 20% 8x/day. The volunteers performed the following treatments: G1 - placebo toothpaste (non-fluoride) three times/day (control group); G2 - fluoride toothpaste in the morning (7:00), before cariogenic challenges, and non-fluoride toothpaste in the next two toothbrushings; and G3- fluoride toothpaste at night (between 20:00 and 21:00), after cariogenic challenges, and non-fluoride toothpaste in the previous two toothbrushings. Enamel-dentin demineralization was evaluated by percentage of surface hardness loss (%SHL). F uptake by enamel and dentin was also determined (as fluorapatite). %SHL data in groups treated with fluoride toothpaste differ from control group (p<0.05), for both enamel (G1=72.0%±20.8; G2=41.6%±21.5; G3=30.0%±15.8) and dentin (G1=76.5%±9.3; G2=61.8%±11.8; G3=48.4±19.1). For dentin, %SHL was lower (p<0.05) in the group using fluoride toothpaste after cariogenic challenges. F concentration in enamel slabs did not differ between groups using fluoride toothpaste (p>0.05), however, it was significantly higher in the group treated with fluoride toothpaste after cariogenic challenges compared to control group (p<0.05). For dentin slabs, groups using fluoride toothpaste showed significantly higher F concentration compared to control group (p<0.05), but no difference was observed between each other (p>0.05). The findings of this study suggest that F from toothpaste is more effective to reduce caries by enhancing enamel-dentine remineralization than by reducing their demineralization (AU) | |
| FAPESP's process: | 09/07019-3 - Frequency of fluoride dentifrice use and enamel and root dentine demineralization |
| Grantee: | Sandro Carvalho Kusano |
| Support Opportunities: | Scholarships in Brazil - Master |