Study of the therapeutic effect of Salmonella enterica Typhimurium attenuated strains in murine models of cancer

Author(s)

Igor Alexandre Campos Damiani

• Document type: Master's Dissertation
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia
• Defense date: 2011-12-16

Examining board members

Marcelo Brocchi; Sueli Fumie Yamada Ogatta; José Andrés Yunes

• Advisor: Marcelo Brocchi

Abstract

Salmonella enterica Typhimurium, a facultative anaerobic bacterium, presents tropism for tumor areas. This interesting property creates new perspectives in cancer research, in which great efforts have been done to seek a drug carrier that could selectively target and destroy malignant cells. Inhibition of tumor growth and even its total elimination were observed in murine cancer models infected by attenuated strains of S. enterica. Besides, its potential as a carrier of exogenous antitumor molecules (DNA vaccine, iRNA, cytokines and enzymes, for example) is also described. Nevertheless, when these strains were tested in humans, they did not induce the same effects observed in murine models. Thus, additional studies are needed to optimize this therapy, including the test of novel S. enterica attenuated strains...Note: The complete abstract is available with the full electronic digital thesis or dissertations (AU)

• FAPESP's process: 09/12659-1 - Study of the therapeutic effect of attenuated strains of Salmonella enterica Typhimurium alone and associated with violacein in different murine models
• Grantee: Igor Alexandre Campos Damiani
• Support Opportunities: Scholarships in Brazil - Master