Full text
| |
| Author(s): |
Fernanda Vieira Ribeiro
Total Authors: 1
|
| Document type: | Master's Dissertation |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba |
| Defense date: | 2007-02-28 |
| Examining board members: |
Marcio Zaffalon Casati;
Giuseppe Alexandre Romito;
Enílson Antonio Sallum
|
| Advisor: | Marcio Zaffalon Casati |
| Abstract | |
The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor, meloxicam, on bone healing around titanium implants in rats. Thirty-one adult male Wistar rats were included in this study and one screw-shaped titanium implant was inserted in the tibiae. The animals were randomly assigned to one of the following groups, for daily subcutaneous injections: Control (n=14): 1 ml/kg of saline solution and Test (n=17): 3 mg/kg of meloxicam, each administered daily for 60 days. After the treatment, the animals were sacrificed and undecalcified sections obtained. Bone-to-implant contact (BIC) and bone filling within the limits of of implant threads (BF) and percentage of bone in a 500µm-wide zone lateral to the implant (BL) were obtained and arranged for cortical (zone A) and cancellous (zone B) bone regions. The data were tested by the Mann-Whitney test (a= 5%). Intergroup comparisons demonstrated that meloxicam significantly reduced bone healing around implants. For zone A, significant differences were observed regarding BIC (47.01 ± 10.48 A; 35.93 ± 12.25 B), BF (86.42 ± 3.66 A; 61.58 ± 12.09 B) and BL (96.86 ± 0.96 A; 91.06 ± 3.05 B) for control and test groups, respectively (p<0.05). For zone B, data analysis also showed significant differences among the groups for BIC (30.76 ± 13.80 A; 16.86 ± 11.48 B), BF (34.83 ± 8.18 A; 25.66 ± 9.16 B) and BL (15.76 ± 7.05 A; 7.73 ± 4.61 B) for control and test groups, respectively (p<0.05). In conclusion, within the limits of the present study, 3 mg/kg/day of meloxicam may negatively influence bone healing in the cortical and cancellous bone around titanium implants inserted in rats after continuous administration (AU) | |