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| Author(s): |
Patrícia Lacouth da Silva
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) |
| Defense date: | 2011-09-22 |
| Examining board members: |
Márcio Reis Custódio;
Jose Roberto Machado Cunha da Silva;
Flavia Pinheiro Zanotto
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| Advisor: | Márcio Reis Custódio |
| Abstract | |
Echinoderms are well known by their regenerative capabilities, mostly in complex events such as the reconstruction of internal organs or entire body parts. However, the knowledge on apparently simpler processes such as wound healing is relatively scarce. It has been described that extracellular matrix remodeling is the main mechanism, and it involves participation of different cells populations. However, the specific function of these cell types is still under debate. In this work, the wound healing process in Holothuria grisea Selenka, 1867 (Holothuriidae) was studied. The lesion was made by an incision through the body wall up to the coelomic cavity. The local changes in cell types and the reorganization of the extracellular matrix were accompanied from 12 hours to 30 days after the injury. Soon after the wound, the organism responded with a localized contraction, followed by cell migration and synthesis of new collagen fibers. Four different cell types were observed, including two different types of spherulocytes. The probable functions of these cells are discussed. (AU) | |
| FAPESP's process: | 08/07189-3 - Cellular mechanisms of regeneration in holothurians (Echinodermata: Holothuroidea): Spherulocytes role |
| Grantee: | Patrícia Lacouth da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |