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| Author(s): |
Carlos Alexandre dos Santos Haemmerle
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2010-09-14 |
| Examining board members: |
Jackson Cioni Bittencourt;
Martin Andreas Metzger;
Renata Hydee Hasue Vilibor
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| Advisor: | Jackson Cioni Bittencourt |
| Abstract | |
MCH is a neuropeptide synthesized preferentially in the hypothalamus that shows projections throughout neuraxis, and may modulate various physiological processes such as food intake. One target of its projections is the nucleus accumbens (Acb), a component of the striatum involved in reward of hedonic stimuli. Our contribution aims to map immunoreactive (ir) cells responsible for the MCH inputs of the Acb, and to investigate appositions between MCH fibers, GABA and ChAT cells. We used the single and double immunoperoxidase methods and immunofluorescence combined with retrograde tracer. The highest density of fiber MCH-ir occupies the shell part of the Acb (AcbSh); MCH-ir inputs are mainly from lateral hypothalamic and perifornical areas. Anterograde controls were obtained from the LHA. We have founded appositions between MCH-ir terminals and GABA- and ChAT-ir cells at AcbSh. Thus, is suggested that hypothalamic areas containing MCH innervate the AcbSh and contact other neurochemical systems systems in the Acb. (AU) | |
| FAPESP's process: | 07/56975-9 - Study of melanin-concentrating hormone (MCH) immunoreactive inputs of nucleus acumbens, in rats Long-Evans |
| Grantee: | Carlos Alexandre dos Santos Haemmerle |
| Support Opportunities: | Scholarships in Brazil - Master |