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| Author(s): |
Marcio Yuiti Tomiyoshi
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2007-12-17 |
| Examining board members: |
Jose Alexandre Marzagao Barbuto;
Niels Olsen Saraiva Câmara;
Frederico Azevedo da Costa Pinto
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| Advisor: | Jose Alexandre Marzagao Barbuto |
| Abstract | |
The communication between the nervous and immune systems contributes to the homeostasis. In humans, living with chronic disease bearers (caregiving) is the causing agent of alterations including the immunological ones. Animal models can contribute for understanding the involved mechanisms. Herein, we evaluated, in healthy females, the alterations caused by cohabiting with a syngeneic (C57Bl/6) partner bearing the B16F10 melanoma. The results showed that such cohabitation for 20 days: 1) altered the behavior without modifying the corticosterone seric level; 2) increased the CD80 expression on MHC+CD11c+ cells at the spleen, but not those at the lymph node; 3) decreased the percentage of MHCII+CD80+ bone marrow cells cultured for 7 days in a GM-CSF, IL-4 and LPS medium. 4) partially inhibited the induction of a delayed type hypersensitivity; 5) did not modified the melanoma establishment. So forth, this model may cautiously be taken as a means for the study of immune alteration observed in caregivers. (AU) | |