Study of the molecular basis involved in the lipolytic effect of thyroid hormone in white adipose tissue.

Author(s)

Carlos Flores Rodrigues Junior

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2011-09-15

Examining board members

Maria Tereza Nunes; Fabio Bessa Lima; Claudia Maria da Penha Oller do Nascimento

• Advisor: Maria Tereza Nunes

Abstract

Thyroid hormones exert a recognized and potent lipolytic effect in white adipose tissue (TAB), yet little is known about the molecular mechanisms involved in these actions. It is known that the main effectors of the lipolytic action in this tissue is hormone-sensitive lipase (HSL) and lipase specific adipocyte triglycerides (ATGL), which hydrolyze triglycerides into fatty acids and glycerol. Other components involved in the lipolytic activity are the beta adrenergic receptors, which recognize their ligands to elevate intracellular cAMP content, with subsequent increased activity of PKA, and perilipin, proteins involving the fat droplet, forming a protective barrier against the action of HSL and ATGL, so that must be hydrolyzed to the HSL and ATGL lipolytic may exert its effect. Considering the importance of body fat for energy homeostasis and that the lipolytic actions of HT have been little explored, and purpose of this study is to investigate whether HT interfere with the expression of the same. (AU)

• FAPESP's process: 09/04832-5 - STUDY OF MOLECULAR BASES INVOLVED THE EFFECT OF LIPOLYTIC THYREOID HORMONES IN THE ADIPOSE TISSUE WHITE
• Grantee: Carlos Flores Rodrigues Júnior
• Support Opportunities: Scholarships in Brazil - Master