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Characterization and modelling of biological networks

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Author(s):
Matheus Palhares Viana
Total Authors: 1
Document type: Doctoral Thesis
Press: São Carlos.
Institution: Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC/BT)
Defense date:
Examining board members:
Luciano da Fontoura Costa; Luiz Antonio Baccala; André Carlos Ponce de Leon Ferreira de Carvalho; Alexandre Gonçalves Evsukoff; Roberto de Alencar Lotufo
Advisor: Luciano da Fontoura Costa
Abstract

In the present work, we developed a mapping methodology able to build a graph representation for biological branched systems. Initially, such systems are stored as digital images and then they undergo a pre-processing in order to standardize the images. The pre-processed imagens are used to build tridimensional models of the interested systems. A label-propagation algorithm is used to extract the skeleton from the volumetric models and these skeletons are then represented by a graph, composed by nodes and edges. The nodes and edges of these graphs store properties of the original system, such as spatial position, lengths and diameter, as well as the topological features of such systems. Finally, the graphs are studied by using the complex networks theory within a specific context for each system. Our procedures were apllied sucefully to different biological systems, such as carotid artery, arterial trees, mitocondrial structure and pores in soil samples. (AU)

FAPESP's process: 07/50882-9 - Characterization and modeling of biological networks
Grantee:Matheus Palhares Viana
Support Opportunities: Scholarships in Brazil - Doctorate