Full text
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| Author(s): |
Aline Teotonio Rodrigues
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2013-05-02 |
| Examining board members: |
Priscila Gava Mazzola;
Celia Regina Garlipp;
Diogo Pilger
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| Advisor: | Priscila Gava Mazzola |
| Abstract | |
The incidence of drug interactions in prescriptions of intensive care units (ICU) is known to exceed the number of interactions than the observed in other hospital settings. The level of technological complexity of this unit, the elevated number of drugs to which patients are exposed and the difficulties inherent in critical care are factors that highlight the need for elaborated evaluation of pharmacotherapy used in intensive care medicine. The role of the clinical pharmacist, composed among other factors, by tracking and detection of theoretical potential drug interactions (TPDI), can be seen as an important contribution to the quality of service and as another security barrier to the use of medication in the ICU. This study is based on the evaluation of a sample of medical prescriptions of ICU and aims to assess the existence of theoretical potential drug interactions in prescriptions made in the Intensive Care Unit (ICU) of a public health hospital (Clinic Hospital - UNICAMP), to quantify and classify them as to their degree of severity, tracing with it a profile of present TPDI in this setting. From January to December 2011, prescriptions of 369 patients were evaluated, all over 18 years old, mean age of 57.03 ± 14.62, hospitalized for more than 24 hours in adult ICU. Two hundred five different types of drugs were prescribed in the study period, average of 13.04 ± 4.26 per prescription. Among the evaluated prescriptions, 89% presented theoretical potential drug interactions, resulting in an average of 5.00 ± 5.06 per prescription. The 405 types of observed TPDI in the prescriptions were classified using database Micromedex ®, highlighting the prevalence of moderate and severe TPDI present in 74% and 67% of prescriptions, respectively. In addition to the data on pharmacotherapeutic profile of ICU under study, it was observed in the survey statistically significant correlation between TPDI and duration of hospital stay in the ICU and the number of prescription drugs. The results contribute to design the relative risk profile of TPDI in intensive care, showing that there is a high incidence of moderate potential drug interactions in prescriptions of ICU. The results emphasized the need for performance of the clinical pharmacist in this area, in order to contribute to the multidisciplinary team to reduce risks from drug therapy (AU) | |
| FAPESP's process: | 11/04645-0 - Drug interaction analysis in medical prescriptions at the Intensive Care Unit (ICU) from Hospital das Clínicas (HC, Unicamp): Relevance of Clinical Pharmacy in Intensive Care Unit (ICU) |
| Grantee: | Aline Teotonio Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Master |