Full text
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| Author(s): |
Mariana dos Santos Silva
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Bauru. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) |
| Defense date: | 2013-06-03 |
| Examining board members: |
Maria Aparecida de Andrade Moreira Machado;
Silgia Aparecida da Costa;
Gustavo Pompermaier Garlet
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| Advisor: | Maria Aparecida de Andrade Moreira Machado |
| Abstract | |
The effect of drugs may be enhanced through the development of new delivery systems as mucoadhesive systems. These systems remain in intimate contact with the tissue absorption, in this case the mucosa, releasing the drug at the site of action, with the consequent increase in bioavailability and may promote local and systemic effects. Mucoadhesion is currently explained by six theories: electronics, adsorption, wetting, diffusion, fracture and mechanics (Carvalho et al., 2010). In 2011, Kloster et al. developed an oral bandage and tested antimicrobial efficiency in the culture of some oral bacteria (S. mutans e C. albicans), the results were promising. The aim of this study was to analyze the biochemical and functional properties of oral antimicrobial bandage with respect to: the salivary environment degradation; the composition adjustment for improving the adherence to the buccal mucous membrane; the performance as to the controlled releasing of drugs; water absorption while analyzing the mass loss; pH measurements of the residual liquid in different periods of time; the plaster cytotoxicity in cell and fibroblast culture. Through the analyzes it was observed that the bandages absorb water and lose mass, it means that they decompose and release their property in the middle. The bandages with drug in viability analysis were cytotoxic cell and different concentrations of drug should be study. (AU) | |
| FAPESP's process: | 11/14667-1 - Biochemical and funcional analyses of oral-aid. |
| Grantee: | Mariana dos Santos Silva |
| Support Opportunities: | Scholarships in Brazil - Master |