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The ubiquitin proteasome system in thyroid hormone-induced cardiac hypertrophy model.

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Author(s):
Caroline Antunes Lino
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas
Defense date:
Examining board members:
Maria Luiza Morais Barreto de Chaves; Julio Cesar Batista Ferreira; Marcelo Damario Gomes
Advisor: Maria Luiza Morais Barreto de Chaves
Abstract

Thyroid gland disorders are often associated with cardiovascular events and hyperthyroidism state promotes cardiac hypertrophy (CH). CH consists in adaptive response characterized by increased synthesis of structural proteins. The Ubiquitin Proteasome System (UPS) is the major mechanism of intracellular proteolysis and increased evidences suggest its involvement in the development of CH. The aim of this study was to evaluate the modulation of UPS in cardiac tissue of animals subjected to hyperthyroidism. The results related to the increased proteasome (PT) activity and expression in the heart was more accentuated in the group treated for 7 days, when the CH process finds stable. At the end of 14 and 21 days of hyperthyroidism, the modulation of cardiac UPS achieves standard values. These results suggest an increased activity of cardiac PT as a compensatory response to protein synthesis induced by thyroid hormones. (AU)

FAPESP's process: 11/01291-3 - THE UBIQUITIN PROTEASOME SYSTEM IN CARDIAC HYPERTROPHY MODEL INDUCED BY THYROID HORMONES.
Grantee:Caroline Antunes Lino
Support type: Scholarships in Brazil - Master