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| Author(s): |
Guilherme Barreto Campos
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-07-17 |
| Examining board members: |
Jorge Timenetsky;
Mauricio Simões Abrão;
Jorge Luiz Mello Sampaio
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| Advisor: | Jorge Timenetsky |
| Abstract | |
Clinical and demographic data, samples of vaginal swab and peripheral blood were obtained from 302 women. Mollicutes, Mycoplasma hominis and M. genitalium were detected in 76.2%, 15.9% and 1.7%, respectively. Frequency of 31.8% and 28.1% in qPCR was found for M. genitalium and M. hominis respectively. Infection by genital mycoplasmas, especially when analyzed by qPCR, was significantly associated with clinical signs and symptoms of sexually transmitted infections. The frequency of Trichomonas vaginalis, Gardnerella vaginalis, Neisseria gonorrhoeae and Chlamydia trachomatis was 3.0%, 21.5%, 42.4% and 1.7% respectively. Co-infection among these species and mycoplasmas was founded. In polymorphism of IL-1b, the genotype CC was more prevalent; however, the T allele was related to small increase of the interleukin levels in the group case. In the polymorphism of IL-6, higher frequency was of the genotype GG, and the GC genotype was associated with increased plasma levels of the cytokine in the group case. Increased levels of IL-1b were associated with presence of M. hominis and signs and/or symptoms of infection. (AU) | |
| FAPESP's process: | 11/03130-7 - Detection of Mycoplasma hominis, M. genitalium and M. penetrans in the female urogenital tract and its relation to genetic polymorphisms and expression of cytokines in women of Vitoria da Conquista - BA |
| Grantee: | Guilherme Barreto Campos |
| Support Opportunities: | Scholarships in Brazil - Master |