Effects of solid lipid nanoparticles containing grape seed extract in diabetic mice cutaneous wound healing.

Author(s)

Juliana da Costa Florim

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2013-07-26

Examining board members

Marinilce Fagundes dos Santos; Vanessa Morais Freitas; Neuza Mariko Aymoto Hassimotto

• Advisor: Marinilce Fagundes dos Santos

Abstract

Oxidative stress caused by hyperglycemia plays an important role in the development and progression of diabetes mellitus (DM) and its complications, such as impaired wound healing. We evaluated the effects of topical administration of solid lipid nanoparticles (SLN) containing grape seed extract on skin wound healing in control and diabetic mice. The results showed a retarded wound closure in diabetic animals, accompanied by a delayed but persistent inflammatory reaction, as well as a significant degree of lipid peroxidation in the dermis. Topical treatment with gel (vehicle), white NLS and NLS associated with grape seed extract were able to efficiently accelerate wound closure and attenuate lipid peroxidation, especially with the application of white NLS and NLS containing Vitaflavan®, proving its antioxidant properties. (AU)

• FAPESP's process: 10/14273-0 - BIODEGRADABLE POLYMERS CONTAINING PROANTOCIANIDINES TO ACCELERATE HEALING OF DIABETIC CHRONIC WOUNDS
• Grantee: Juliana da Costa Florim
• Support Opportunities: Scholarships in Brazil - Master