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| Author(s): |
Ligiana Pires Corona
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) |
| Defense date: | 2014-02-26 |
| Examining board members: |
Yeda Aparecida de Oliveira Duarte;
Marcelo Gil Cliquet;
Andre Fattori;
Luiz Eugenio Garcez Leme;
Maria de Fátima Nunes Marucci
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| Advisor: | Yeda Aparecida de Oliveira Duarte |
| Abstract | |
Introduction: Anemia is the most commonly hematologic disorder in older adults, with a prevalence of approximately 10 per cent in community-living elderly. It is associated with several chronic diseases and other adverse health outcomes, such as impaired mobility, frailty and difficulties in activities of daily living (ADL). Objective: To evaluate factors associated to anemia and its relationship with adverse health outcomes in the older adults living in São Paulo, Brazil. Methods: An observational cross-sectional population-based study, with a representative sample, which evaluated 1256 elderly ( 60 years) in 2010. The hemoglobin blood concentration was considered continuous or categorized as anemia according to WHO cutoffs (women: <12g/dL; Men: <13g/dL). We used hierarchical logistic regression to assess factors associated with the presence of anemia, and to evaluate the association of anemia with adverse health outcomes. Results: The prevalence of anemia was 7.7 per cent , among older adults, and the factors that remain statistically significant after adjustment are higher age, presence of diabetes, cancer and depressive symptoms. When considering adverse health outcomes, anemia remained significantly associated with frailty (OR=5.19, 95 per cent CI=2.41,11.20) and mobility difficulty (OR=2.10, 95 per cent CI=1.19, 3.69). Hemoglobin continuous concentration showed negative effect on the probability of outcomes - the higher the blood hemoglobin, the less chance of frailty (OR=0.91, 95 per cent CI=1.03,1.08) and mobility difficulty (OR=0,81, 95 per cent CI=0.67, 0.97). The probabilities of outcomes when the current cutoffs for anemia are adopted are about 20 per cent . Conclusion: The prevalence of anemia in the older adults in São Paulo is close to the values found in other populations. The disease was associated with advanced age, presence of diabetes, cancer and depressive symptoms. Among health outcomes, anemia was associated to impaired mobility and frailty.The high probability of outcomes when the current WHO cutoff are take into account reinforces the discussion of rising the cutoff points for the older population, and even if it brings a greater burden for health services, it could help health professionals in early intervention for treatment of anemia, and thus prevent, delay or reverse the adverse outcomes. (AU) | |
| FAPESP's process: | 10/02779-7 - Anemia in the elderly: associated factors and impact on frailty status - SABE Project |
| Grantee: | Ligiana Pires Corona |
| Support Opportunities: | Scholarships in Brazil - Doctorate |