CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy-Biochemistry: Faculty of Pharmaceutical Sciences of Araraquara, UNESP (1978), Master and PhD in Biochemistry: Faculty of Medicine of Ribeirão Preto, USP (1983 and 1986, respectively). Currently, is Associated Professor at Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP, Department of Physics and Chemistry. Works in Biochemistry, with implications in pharmacology, toxicology and pathology: Bioenergetic and reactive oxygen species in mitochondria, the organelles function in cell survival/death, metabolism and signaling involving the organelles in cancer. Studies mitochondria and tumor cells in culture, using molecular and cellular biology aproaches. (Source: Lattes Curriculum)
This project aims to continue the study of the molecular and biochemical actions of SET protein in tumorigenesis and progression and spread of solid tumors using as model/experimental approach head and neck squamous cell carcinoma (HNSCC). The main front research is based on the impact of this protein in intracellular signaling pathways important for tumorigenesis. At the molecular level,…
Tumor cells, in particular of head and neck scamous cell carcinoma (HNSCC), present as important characteristic the resistance to undergo apoptosis, which reflects both in aggressiveness of cancer and inefficiency of treatment against the disease. The present study proposes to assess molecular mechanisms of resistance of apoptosis signaling in HN13 cells (oral scamous cell carcinoma) comp…
| 6 / 2 | Completed research grants |
| 7 / 0 | Completed scholarships in Brazil |
| 13 / 2 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 14 |
| Citations | 163 |
| Cit./Article | 11.6 |
| Data from Web of Science | |
ALMEIDA, LUCIANA O.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; TANNOUS, MARYNA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. ONCOTARGET, v. 8, n. 16, p. 26802-26818, APR 18 2017. Web of Science Citations: 6. (09/52228-0, 13/10898-4, 10/20384-0, 10/20536-4, 13/08135-2, 09/10783-7)
SOBRAL, LAYS M.; SOUSA, LUCAS O.; COLETTA, RICARDO D.; CABRAL, HAMILTON; GREENE, LEWIS J.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer, v. 13, FEB 20 2014. Web of Science Citations: 26. (10/18544-9, 09/52228-0, 13/10898-4, 10/20384-0, 13/08135-2)
SOBRAL, LAYS M.; COLETTA, RICARDO D.; ALBERICI, LUCIANE C.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS Journal, v. 284, n. 17, p. 2774-2785, SEP 2017. Web of Science Citations: 4. (13/08135-2, 10/18544-9, 13/10898-4)
LEOPOLDINO, ANDREIA M.; SQUARIZE, CRISTIANE H.; GARCIA, CRISTIANA B.; ALMEIDA, LUCIANA O.; PESTANA, CEZAR R.; SOBRAL, LAYS M.; UYEMURA, SERGIO A.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS. SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncology, v. 48, n. 11, p. 1106-1113, NOV 2012. Web of Science Citations: 23. (10/20384-0, 09/52228-0, 06/06334-4, 05/03380-2)
ALMEIDA, LUCIANA O.; GARCIA, CRISTIANA B.; MATOS-SILVA, FLAVIA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochemical and Biophysical Research Communications, v. 445, n. 1, p. 196-202, FEB 28 2014. Web of Science Citations: 9. (07/02223-6, 09/52228-0, 13/10898-4, 10/20384-0, 09/10783-7)
ALMEIDA, LUCIANA O.; GOTO, RENATA N.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario. Biochemical and Biophysical Research Communications, v. 458, n. 2, p. 300-306, MAR 6 2015. Web of Science Citations: 5. (09/52228-0, 13/10898-4, 10/20384-0, 13/01355-7, 09/10783-7)
SOUSA, LUCAS OLIVEIRA; SOBRAL, LAYS MARTIN; DE ALMEIDA, LUCIANA OLIVEIRA; GARCIA, CRISTIANA BERNADELLI; GREENE, LEWIS JOEL; LEOPOLDINO, ANDREIA MACHADO. SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma. Epigenomics, v. 12, n. 6, p. 475-485, MAR 2020. Web of Science Citations: 0. (10/20384-0, 16/19103-2, 13/10898-4, 13/08135-2)
GOTO, RENATA NISHIDA; SOBRAL, LAYS MARTIN; SOUSA, LUCAS OLIVEIRA; GARCIA, CRISTIANA BERNADELLI; LOPES, NORBERTO PEPORINE; MARIN-PRIDA, JAVIER; OCHOA-RODRIGUEZ, ESTAEL; VERDECIA-REYES, YAMILA; LAZARO PARDO-ANDREU, GILBERTO; CURTI, CARLOS; et al. Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma. European Journal of Pharmacology, v. 819, p. 198-206, JAN 15 2018. Web of Science Citations: 13. (13/01355-7, 13/10898-4)
OUCHIDA, AMANDA TOMIE; UYEMURA, VALERIA TUDELLA; QUEIROZ, ANDRE LIMA; BRAUER, VERONICA SOARES; CAVALCANTI-NETO, MARINALDO PACIFICO; SOUSA, LUCAS OLIVEIRA; UYEMURA, SERGIO AKIRA; CURTI, CARLOS; LEOPOLDINO, ANDREIA MACHADO. SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1866, n. 4, p. 623-637, APR 2019. Web of Science Citations: 1. (09/52228-0, 13/10898-4, 16/19103-2)
RODRIGUES, FERNANDO P.; CARNEIRO, ZUMIRA A.; MASCHARAK, PRADIP; CURTI, CARLOS; DA SILVA, ROBERTO S.. Incorporation of a ruthenium nitrosyl complex into liposomes, the nitric oxide released from these liposomes and HepG2 cell death mechanism. Coordination Chemistry Reviews, v. 306, n. 2, SI, p. 701-707, JAN 1 2016. Web of Science Citations: 20.
LEOPOLDINO, ANDREIA M.; SQUARIZE, CRISTIANE H.; GARCIA, CRISTIANA B.; ALMEIDA, LUCIANA O.; PESTANA, CEZAR R.; POLIZELLO, ANA C. M.; UYEMURA, SERGIO A.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS. Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Molecular and Cellular Biochemistry, v. 363, n. 1-2, p. 65-74, APR 2012. Web of Science Citations: 19. (05/03380-2, 09/52228-0, 06/06334-4)
LAPA‚ R.A.S.; LIMA‚ J.L.F.C.; REIS‚ B.F.; SANTOS‚ J.L.M.; ZAGATTO‚ E.A.G.. Photochemical-fluorimetric determination of folic acid in a multicommutated flow system. Analytica Chimica Acta, v. 351, n. 1-3, p. 223-228, 1997.
ALMEIDA, LUCIANA O.; GOTO, RENATA N.; PESTANA, CEZAR R.; UYEMURA, SERGIO A.; GUTKIND, SILVIO; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. FEBS Journal, v. 279, n. 24, p. 4615-4628, DEC 2012. Web of Science Citations: 12. (09/52228-0, 10/20384-0, 10/20536-4, 09/10783-7)
GOTO, RENATA NISHIDA; SOBRAL, LAYS MARTIN; STRINGHETTA-PADOVANI, KARINA; GARCIA, CRISTIANA B.; DA SILVA, GABRIEL; VITEK, MICHAEL P.; LEOPOLDINO, ANDREIA MACHADO. Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. European Journal of Pharmacology, v. 882, SEP 5 2020. Web of Science Citations: 0. (13/00374-8, 13/01355-7, 13/10898-4, 18/17480-9, 16/19103-2, 13/08135-2)