Thomas Prates Ong

• 15th National Congress of the Brazilian Society of Food and Nutrition (SBAN), AO.R

• Abstract

  Breast cancer is a major public health problem. One intriguing hypothesis that has not gained much attention in the literature, despite its biological plausibility, is that cancer, including breast cancer, has a fetal origin. Although the fetal hypothesis has been investigated mainly in the context of other non-communicable diseases including cardiovascular disease, obesity and type II di…

  Maternal nutrition and breast cancer fetal programming: influence of nutrient-epigenome interactions in early life, AP.R

• Abstract

  Breast cancer is a multifactorial disease, in which risk factors such as eating habits, exercise, sex, age and genetic factors are associated with the tumor. It is a hormone-dependent disease, in which estrogen stands out, whose direct actions increase the risk for the development of breast cancer. Although estrogen is the main hormone studied in this area, currently interest has also bee…

  Selenium and cell proliferation inhibition in breast cancer: the role of the micronutrient on prolactin pathway focusing on miR-106b and its target p21, BP.IC

• Abstract

  Breast cancer represents an important public health problem. In particular, obesity was identified as a major risk factor for cancer. An intriguing hypothesis that has received little attention in the literature considers that father malnutrition might influence the risk of their daughters developing breast cancer. In a PhD project to which this research project is linked, male mice were …

  Evaluation of development and epigenetic marks of the mammary gland from female offspring of obese male rats that received or not orange juice, BP.IC

• Abstract

  Maternal and more recently paternal nutritional patterns may influence offspring susceptibility to chronic diseases, including breast cancer. Embryonic/fetal period is characterized by rapid cell division and differentiation and inadequate nutritional conditions in early life may program altered phenotypes in adult life. On the other hand, early development may comprise a relevant window …

  Blackberry (Rubus spp.) extract maternal and/or paternal consumption effects on female offspring susceptibility to chemically-induced breast carcinogenesis, BP.DR

(Only some records are available in English at this moment)

• Abstract

  Breast cancer is a significant public health problem, representing a major cause of death in women both in the USA and in Brazil. Dietary factors have been identified as important modulators of the risk of developing cancer. Based on epidemiological studies and animal models, the essential micronutrient selenium has been highlighted as a promising dietary factor associated to breast cance…

  Analysis of morphological and epigenetic parameters in the mammary gland of female offspring of rats exposed to selenium deficiency or supplementation during gestation, BE.EP.DD

• Abstract

  As described for other non-communicable chronic diseases, it is also hypothesized that breast cancer would have a fetal origin. In 1990, Trichopoulos suggested that some breast cancer were programmed in the intrauterine environment due to exposure to high levels of estrogen. An inadequate food intake by women during pregnancy may be particularly important to modify the fetal environment a…

  Morphological and global gene expression analysis of mammary tissue of young female rats treated in utero with high-saturated fatty acid diet, BE.EP.DR